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KMID : 0366220100450010073
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Korean Journal of Hematology
2010 Volume.45 No. 1 p.73 ~ p.75
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A case of subdural hematoma in patient with chronic myeloid leukemia treated with high-dose imatinib mesylate
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Kim Min-Sik
Kim Ki-Uk
Kim Sung-Hyun
Lee Dong-Hyun
Lee Yu-Rim
Kim Dong-Gyun
Bae Suk-Hyang
Hwang Jin-Yeon
Kwon Kyung-A
Lee Suee
Han Jin-Yeong
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Abstract
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Imatinib mesylate (IM) is used to treat a wide range of diseases, including Philadelphia chromosome-positive chronic myeloid leukemia (CML), on account of its high tolerability and low incidence of minor adverse events. Hemorrhage is thought to be a rare complication of IM. Recently, IM has been associated with reduced a2-plasmin inhibitor and platelet dysfunction. We report here the case of a 33-year-old female patient with CML who experienced subdural hematoma after an incremental increase in IM dosage due to a loss of complete molecular response. This case indicates that physicians should be alert to this atypical cause of headache in patients taking high-dose IM.
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KEYWORD
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Chronic myeloid leukemia, Imatinib mesylate, Subdural hematoma
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